Atazanavir and the enzyme UGT1A1
Atazanavir inhibits the enzyme UGT1A1. UGT1A1 is the only enzyme in the body that can make bilirubin water-soluble so that it can be excreted in bile by the liver. Bilirubin is a waste product that is released when red blood cells are broken down and is toxic to the body. It causes jaundice (hyperbilirubinaemia) and, depending on your genetic predisposition to reduced UGT1A1 enzyme activity, you may be at an increased risk of developing this condition. People who have two UGT1A1 decreased-function alleles are most at risk of developing jaundice. The UGT1A1 enzyme is not involved in breaking down atazanavir.
Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with atazanavir.
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